Antioxidant Activity of Goat Milk Yogurt Casein on Dioxin Intoxicated Rat Liver Function

Authors

  • Ani Setianingrum Faculty of Veterinary Medicine, Universitas Brawijaya
  • Masdiana Chendrakasih Padaga Faculty of Veterinary Medicine, Universitas Brawijaya

Keywords:

Casein yogurt, dioxin, ALT, AST, GGT

Abstract

Dioxin is toxic contaminant which persistent in the environment. This compound bio-accumulate through food chain and generate adverse effect in human health. Oxidative stress due to dioxin exposure can interfere metabolism process and leads to the development of hepatotoxicity.The aim of this study was to asses the role of casein derived from goat milk yogurt in dioxin-intoxicated rat based on liver function parameters. Substances used were: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) diluted in corn oil and casein from goat milk yogurt. The study included 24 Wistar rats divided into 6 groups: (1) control group, (2) placebo group which given casein 600 mg/kg BW, (3) TCDD group given with TCDD 100 ng/kg BW, (4) group P1 given casein 300 mg/kg BW and TCDD, (5) group P2 given casein 600 mg/kg BW and TCDD, (6) group P3 given casein 900 mg/kg BW and TCDD. The respective dose were given orally for 21 days. Blood serum was collected for transaminases (ALT, AST) and γ-glutamyl transferase (GGT) analysis. Based on serum transaminases activity, there were no significant change on AST and ALT level. Casein yogurt supplementation has significant effect on serum GGT level (p<0,05) and optimum dose was 600 mg/kg BW/day

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Published

2019-01-29

How to Cite

Setianingrum, A., & Padaga, M. C. (2019). Antioxidant Activity of Goat Milk Yogurt Casein on Dioxin Intoxicated Rat Liver Function. Veterinary Biomedical and Clinical Journal, 1(1), 26–32. Retrieved from https://vbcj.ub.ac.id/index.php/vbcj/article/view/7

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